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These types of medication blocks an enzyme called cyclooxygenase (COX). COX is responsible for the promotion of inflammation, pain, and fever. Using a NSAIDS cream will allow for localize pain relief cream to help treat pain.

Anesthetics Topical Cream
Anesthetics can be used to relieve pain and numb the area the cream is applied to. Anesthetic are used to help relieve with certain conditions like burns, abrasions, sore throat, post-herpetic neuralgia (post-shingles), arthritis and hemorrhoids. It works by blocking the permeability of neuronal membrane causing the neuron the neuron membrane to stabilize and prevent the transmission and receiving of messages causing a "numbing" feeling.

Muscle Relaxants Topical Cream
Muscle Relaxants like cyclobenzaprine work by blocking nerve signals from being sent to the brain. These nerve signals are what give the body pain sensations.

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